Advanced potency, easy cadence. Reap the rewards. Our highest concentration Regimen, ideal for skin that is preconditioned with Ramp-Up Regimen 2. Regimen 3 is comprised of R3 Opoule Treatment 0.1% Retinol and the RHR Overnight Mask. Includes four week supply of Retinol+ Ramp-Up Regimen 3.